Go 6976

(HB0302)

Product overview

  • Name
    Go 6976
  • Short description
    Potent, selective PKC inhibitor
  • Biological description
    Potent and selective protein kinase C (PKC) inhibitor at α and β1 subunits (IC50 values are 2.3 and 6.2 nM respectively). Displays no activity at ε, δ, and ζ PKC subunits. Also a protein kinase D (IC50 = 20 nM), JAK 2, FLT3, TrkB and TrkA tyrosine kinases inhibitor. Displays antitumor properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
  • Molecular Weight
    378.43
  • Chemical structure
    Go 6976  [136194-77-9]
  • Molecular Formula
    C24H18N4O
  • CAS Number
    136194-77-9
  • PubChem identifier
    3501
  • SMILES
    CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Go 6976

  • Gö 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.

    Behrens MM et al (1999) J Neurochem 72(3) : 919-24.
    PubMedID: 10037462
  • Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.

    Grandage VL et al (2006) Br J Haematol 135(3) : 303-16.
    PubMedID: 16956345
  • Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

    Martiny-Baron G et al (1993) J Biol Chem 268(13) : 9194-7.
    PubMedID: 8486620
  • Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes.

    Shapiro BA et al (2002) J Pharmacol Exp Ther 302(1) : 352-8.
    PubMedID: 12065737

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