Product overview

  • Name
    Go 6983
  • Short description
    Broad spectrum PKC inhibitor
  • Biological description
    Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 nM and 20 µM for PKC-α, PKC-β, PKC-γ, PKC-δ, PKC-ζ and PKC-µ respectively). Also suppresses TNF-α production (IC50 = 8.3 nM) and up-regulates Akt phosphorylation. Displays cardioprotective properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Molecular Weight
    442.51
  • Chemical structure
    Go 6983  [133053-19-7]
  • Molecular Formula
    C26H26N4O3
  • CAS Number
    133053-19-7
  • PubChem identifier
    3499
  • SMILES
    CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
  • InChi
    InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
  • InChiKey
    LLJJDLHGZUOMQP-UHFFFAOYSA-N
  • MDL number
    MFCD04040031

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Go 6983

  • Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.

    Young LH et al (2005) Cardiovasc Drug Rev 23(3) : 255-72.
    PubMedID: 16252018
  • Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.

    Foey AD et al (2004) Immunology 112(1) : 44-53.
    PubMedID: 15096183
  • Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.

    Gschwendt M et al (1996) FEBS Lett 392(2) : 77-80.
    PubMedID: 8772178
  • PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.

    Kim SY et al (2011) BMB Rep 44(2) : 140-5.
    PubMedID: 21345315

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