Product overview

  • Name
    Gossypol
  • Short description
    Dehydrogenase enzyme inhibitor
  • Biological description
    Dehydrogenase enzyme inhibitor. Bcl-2 homology 3 (BH3)-mimetic agent, binds to the BH3 domain of members of the B-cell lymphoma 2 (Bcl-2) family. Inhibits APE-1 (apurinic/apyrimidinic endonuclease 1) activity. Shows antioxidant, antiviral, antiparasitic, apoptotic and anticancer actions.
  • Biological action
    Inhibitor
  • Purity
    >90%
  • Our products in action

Properties

  • Chemical name
    Pogosin; AT101
  • Molecular Weight
    518.56
  • Chemical structure
    Gossypol  [303-45-7]
  • Molecular Formula
    C30H30O8
  • CAS Number
    303-45-7
  • PubChem identifier
    3503
  • SMILES
    CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C

Storing and Using Your Product

  • Solubility overview
    soluble in ethanol (25mg/ml) or DMF (25mg/ml)

References for Gossypol

  • Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.

    Qian C et al (2014) Drug Des Devel Ther 8 : 485-96.
    PubMedID: 24872679
  • Gossypol: a contraceptive for men.

    Coutinho EM (2002) Contraception 65(4) : 259-63.
    PubMedID: 12020773
  • Gossypol: prototype of inhibitors targeted to dinucleotide folds.

    Vander Jagt DL et al (2000) Curr Med Chem 7(4) : 479-98.
    PubMedID: 10702620
  • Therapeutic potential of gossypol: an overview.

    Keshmiri-Neghab H et al (2014) Pharm Biol 52(1) : 124-8.
    PubMedID: 24073600

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