Product overview

  • Name
    GSK J1
  • Short description
    Potent, selective histone demethylase KDM6 subfamily inhibitor
  • Biological description
    Potent and selective histone demethylase KDM6 subfamily inhibitor, selective for JMJD3 and UTX (IC50 = 60 nM for human JMJD3). Reduces macrophage proinflammatory cytokine production.
  • Alternative names
    GSK-J1
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetra hydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanin e
  • Molecular Weight
    389.45
  • Chemical structure
    GSK J1  [1373422-53-7]
  • Molecular Formula
    C22H23N5O2
  • CAS Number
    1373422-53-7

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for GSK J1

  • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

    Kruidenier L et al (2012) Nature 488(7411) : 404-8.
    PubMedID: 22842901

Reviews & Product Guides