GYKI 52466 hydrochloride

(HB0311)

Product overview

  • Name
    GYKI 52466 hydrochloride
  • Short description
    Selective, non-competitive AMPA receptor antagonist
  • Biological description
    Selective, non-competitive AMPA receptor antagonist (IC50 values are 11 and 7.5 µM for AMPA and kainate receptors respectively). Inactive at NMDA receptors. Shows anti-convulsant and neuroprotective actions.
  • Alternative names
    GYKI-52466
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine hydrochloride
  • Molecular Weight
    329.79
  • Chemical structure
    GYKI 52466  [102771-26-6]
  • Molecular Formula
    C17H15N3O2.HCl
  • CAS Number
    102771-26-6
  • PubChem identifier
    10042240
  • SMILES
    Cl.Nc1ccc(cc1)C3=NN=C(C)Cc2cc4OCOc4cc23

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Storage buffer
    room temperature (desiccate)
  • Solubility overview
    soluble in water (10mM) or DMSO (25mM, heating)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for GYKI 52466 hydrochloride

  • GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses.

    Donevan SD et al (1993) Neuron 10(1) : 51-9.
    PubMedID: 7678966
  • Pharmacological Preconditioning with GYKI 52466: A Prophylactic Approach to Neuroprotection.

    Goulton CS et al (2010) Front Neurosci 4 :
    PubMedID: 20953290
  • Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.

    Szabados T et al (2001) Brain Res Bull 55(3) : 387-91.
    PubMedID: 11489346