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Biological Data
| Biological description | PKG (cGPK), PKA, PKC, Myosin light chain kinase (MLCK), Casein kinase (CK) 1 and 2 inhibitor (Ki values are 0.48, 1.2, 15, 68, 133 and 950 µM respectively). Blocks cell cycle progression. |
Solubility & Handling
| Solubility overview | Soluble in DMSO (25mg/ml) or ethanol:water (25mg/ml, ratio 1:1) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamidedihydrochloride |
| Chemical structure | ![H-8 [84478-11-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "H-8 [84478-11-5]") |
| Molecular Formula | C12H15N3O2S.2HCl |
| PubChem identifier | 150584 |
| SMILES | CNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2.Cl.Cl |
References for H-8
References are publications that support the biological activity of the product
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Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.
Ido M et al (1991) Br J Cancer 64(6) : 1103-7. -
Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.
Ido M et al (1991) Br J Cancer 64(6) : 1103-7. -
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
Hidaka H et al (1984) Biochemistry 23(21) : 5036-41.
![H-8 [84478-11-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0318.png "H-8 [84478-11-5]")
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