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Data

Product overview

  • Name
    H-8
  • Short description
    PKA / PKG inhibitor
  • Biological description
    PKG (cGPK), PKA, PKC, Myosin light chain kinase (MLCK), Casein kinase (CK) 1 and 2 inhibitor (Ki values are 0.48, 1.2, 15, 68, 133 and 950 µM respectively). Blocks cell cycle progression.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamidedihydrochloride
  • Molecular Weight
    338.25
  • Chemical structure
    H-8  [84478-11-5]
  • Molecular Formula
    C12H15N3O2S.2HCl
  • CAS Number
    84478-11-5
  • PubChem identifier
    150584
  • SMILES
    CNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2.Cl.Cl

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO (25mg/ml) or ethanol:water (25mg/ml, ratio 1:1)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for H-8

  • Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.

    Ido M et al (1991) Br J Cancer 64(6) : 1103-7.
    PubMedID: 1684908
  • Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

    Hidaka H et al (1984) Biochemistry 23(21) : 5036-41.
    PubMedID: 6238627
  • Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.

    Ido M et al (1991) Br J Cancer 64(6) : 1103-7.
    PubMedID: 1684908
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