H 89 dihydrochloride

(HB0314)

Product overview

  • Name
    H 89 dihydrochloride
  • Short description
    Potent, non-selective kinase inhibitor
  • Biological description
    Potent, non-selective kinase inhibitor. Protein kinase A inhibitor (IC50 = 135 nM). Also inhibits S6K1, MSK1, ROCKII, PKBα and MAPKAP-Klb (IC50 values are 80, 120 and 270 nM, 2.6 µM and 2.8 µM respectively).
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride
  • Molecular Weight
    519.28
  • Chemical structure
    H 89 dihydrochloride  [130964-39-5]
  • Molecular Formula
    C20H20BrN3O2S.2HCl
  • CAS Number
    130964-39-5

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in water (25mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for H 89 dihydrochloride

  • The many faces of H89: a review.

    Lochner A et al (2006) Cardiovasc Drug Rev 24(3-4) : 261-74.
    PubMedID: 17214602
  • Involvement of cAMP response element-binding protein activation in salivary secretion.

    Yamada K et al (2006) Pathobiology 73(1) : 1-7.
    PubMedID: 16785762
  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    PubMedID: 10998351
  • Pharmacological PKA inhibition: all may not be what it seems.

    Murray AJ (2008) Sci Signal 1(22) : re4.
    PubMedID: 18523239

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