HC 030031

(HB1158)

Product overview

  • Name
    HC 030031
  • Short description
    Selective TRPA1 channel blocker
  • Biological description
    Selective TRPA1 channel blocker (IC50 values are 0.7 and 1.2 µM for AITC- and formalin activated TRPA1 channels respectively). Displays little or no activity at TRPV1, TRPV3, TRPV4, hERG and Nav1.2 channels (IC50 values >10 µM). Also anatgonizes AITC- and formalin evoked Ca2+ influx (IC50 values are 6.2 and 5.3 µM respectively). Attenuates neuropathy- and inflammatory- induced mechanical hypersensitivity.
  • Biological action
    Blocker
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acet amide
  • Molecular Weight
    355.39
  • Chemical structure
    HC 030031  [349085-38-7]
  • Molecular Formula
    C18H21N5O3
  • CAS Number
    349085-38-7

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for HC 030031

  • HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.

    Eid SR et al (2008) Mol Pain 4 : 48
    PubMedID: 18954467
  • TRPA1 mediates formalin-induced pain.

    McNamara CR et al (2007) Proc Natl Acad Sci U S A 104(33) : 13525-30.
    PubMedID: 17686976
  • Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia.

    Ro JY et al (2009) Pain 144(3) : 270-7.
    PubMedID: 19464796

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