In my cart

You have no items in your shopping cart.

Data

Product overview

  • Name
    HC 067047
  • Short description
    Potent, selective TRPV4 channel antagonist
  • Biological description
    Potent and selective TRPV4 channel antagonist (IC50 values are 17, 48 and 133 nM for mouse, human and rat TRPV4 channels respectively). Increases ATP release from porcine lenses (IC50 = 2.5 µM). Also reduces 4α-phorbol 12,13-didecanoate (4α-PDD)-induced Ca2+ responses (IC50 = 22 nM). Exhibits reduced activity for TRPM8 and hERG channels.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Images

Properties

  • Chemical name
    2-Methyl-1-[3-(4-morpholinyl)propyl ]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
  • Molecular Weight
    471.5
  • Chemical structure
    HC 067047  [883031-03-6]
  • Molecular Formula
    C26H28F3N3O2
  • CAS Number
    883031-03-6
  • PubChem identifier
    2742550
  • SMILES
    CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F
  • Source
    Synthetic
  • InChi
    InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
  • InChiKey
    NCZYSQOTAYFTNM-UHFFFAOYSA-N
  • MDL number
    MFCD01571257
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for HC 067047

  • TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.

    Shahidullah M et al (2012) Am J Physiol Cell Physiol 302(12) : C1751-61.
    PubMedID: 22492652
  • Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.

    Dahan D et al (2012) Am J Physiol Lung Cell Mol Physiol 303(9) : L824-33.
    PubMedID: 22962011
  • Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.

    Everaerts W et al (2010) Proc Natl Acad Sci U S A 107(44) : 19084-9.
    PubMedID: 20956320
Support & Resources

Reviews & Product Guides