Product overview

• Name
  HC 067047
• Short description
  Potent, selective TRPV4 channel antagonist
• Biological description
  Potent and selective TRPV4 channel antagonist (IC₅₀ values are 17, 48 and 133 nM for mouse, human and rat TRPV4 channels respectively). Increases ATP release from porcine lenses (IC₅₀ = 2.5 µM). Also reduces 4α-phorbol 12,13-didecanoate (4α-PDD)-induced Ca²⁺ responses (IC₅₀ = 22 nM). Exhibits reduced activity for TRPM8 and hERG channels.
• Biological action
  Antagonist
• Purity
  >98%
• Citations
  Submit Your Citation Now

Images

Properties

• Chemical name
  2-Methyl-1-[3-(4-morpholinyl)propyl ]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
• Molecular Weight
  471.5
• Chemical structure
  
• Molecular Formula
  C₂₆H₂₈F₃N₃O₂
• CAS Number
  883031-03-6
• PubChem identifier
  2742550
• SMILES
  CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F
• Source
  Synthetic
• InChi
  InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
• InChiKey
  NCZYSQOTAYFTNM-UHFFFAOYSA-N
• MDL number
  MFCD01571257
• Appearance
  White solid

Storing and Using Your Product

• Storage instructions
  +4°C
• Solubility overview
  Soluble in DMSO (100mM) and in ethanol (25mM)
• Important
  This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.