HC 067047
(HB1191)- Data
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Data
Product overview
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NameHC 067047
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Short descriptionPotent, selective TRPV4 channel antagonist
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Biological descriptionPotent and selective TRPV4 channel antagonist (IC50 values are 17, 48 and 133 nM for mouse, human and rat TRPV4 channels respectively). Increases ATP release from porcine lenses (IC50 = 2.5 µM). Also reduces 4α-phorbol 12,13-didecanoate (4α-PDD)-induced Ca2+ responses (IC50 = 22 nM). Exhibits reduced activity for TRPM8 and hERG channels.
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Biological actionAntagonist
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Purity>98%
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Properties
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Chemical name2-Methyl-1-[3-(4-morpholinyl)propyl ]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
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Molecular Weight471.5
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Chemical structure
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Molecular FormulaC26H28F3N3O2
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CAS Number883031-03-6
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PubChem identifier2742550
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SMILESCC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F
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SourceSynthetic
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InChiInChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
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InChiKeyNCZYSQOTAYFTNM-UHFFFAOYSA-N
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MDL numberMFCD01571257
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AppearanceWhite solid
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in DMSO (100mM) and in ethanol (25mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for HC 067047
TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.
Shahidullah M et al (2012) Am J Physiol Cell Physiol 302(12) : C1751-61.PubMedID: 22492652Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats.
Dahan D et al (2012) Am J Physiol Lung Cell Mol Physiol 303(9) : L824-33.PubMedID: 22962011Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.
Everaerts W et al (2010) Proc Natl Acad Sci U S A 107(44) : 19084-9.PubMedID: 20956320
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