Herbimycin A

(HB1325)

Product overview

  • Name
    Herbimycin A
  • Short description
    Src family kinase inhibitor
  • Biological description
    Src family kinase inhibitor. Inhibits Hsp90 in the heat shock response. Inhibits IκB kinase β and suppresses NF-κB. Shows anti-inflammatory, antibiotic and anti-angiogenic actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    (15R)-17-demethoxy-15-methoxy-11-O- methyl-geldanamycin
  • Molecular Weight
    574.67
  • Molecular Formula
    C30H42N2O9
  • CAS Number
    70563-58-5

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Herbimycin A

  • Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.

    McCollum GW et al (2004) Exp Eye Res 78(5) : 987-95.
    PubMedID: 15051479
  • Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.

    Ogino S et al (2004) Mol Pharmacol 65(6) : 1344-51.
    PubMedID: 15155828
  • Inhibition of Hsp90 function delays and impairs recovery from heat shock.

    Duncan RF (2005) FEBS J 272(20) : 5244-56.
    PubMedID: 16218955

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