Homoharringtonine

(HB4660)

Product overview

  • Name
    Homoharringtonine
  • Short description
    Protein synthesis inhibitor
  • Biological description
    Protein synthesis inhibitor. Prevents substrate binding to the acceptor site on the 60S ribosome subunit to inhibit the elongation phase of translation. Shows antileukemic and antitumor activity. Active in vivo.
  • Alternative names
    HHT | Omacetaxine mepesuccinate
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
  • Molecular Weight
    545.63
  • Chemical structure
    Homoharringtonine [26833-87-4]
  • Molecular Formula
    C29H39NO9
  • CAS Number
    26833-87-4
  • PubChem identifier
    285033
  • SMILES
    CC(C)(CCC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
  • InChi
    InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
  • InChiKey
    HYFHYPWGAURHIV-JFIAXGOJSA-N
  • MDL number
    MFCD03410264
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

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