Product overview

Name Homoharringtonine
Alternative names HHT | Omacetaxine mepesuccinate
Purity >98%
Description Protein synthesis inhibitor
Write Your Own Review
You're reviewing:Homoharringtonine
Rate this item:

Biological Data

Biological description

Protein synthesis inhibitor which prevents substrate binding to the acceptor site on the 60S ribosome subunit to inhibit the elongation phase of translation.

Shows antileukemic and antitumor activity. Active in vivo.

Inhibits SARS-Cov2 (EC50 = 2.1µM).

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Molecular Weight 545.63
Chemical structure Homoharringtonine [26833-87-4] Chemical Structure
Molecular Formula C29H39NO9
CAS Number 26833-87-4
PubChem identifier 285033
SMILES CC(C)(CCC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
InChi InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChiKey HYFHYPWGAURHIV-JFIAXGOJSA-N
MDL number MFCD03410264
Appearance White solid

References for Homoharringtonine

References are publications that support the biological activity of the product
  • Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

    Choy et al (2020) Antiviral Res. 178 : 104786
  • Homoharringtonine: an effective new natural product in cancer chemotherapy

    Zhou et al (1995) Bull Cancer. 82(12) : 978-95.
  • Inhibition of translation in eukaryotic systems by harringtonine

    Fresno et al (1977) Eur J Biochem. 72(2) : 323-30

3 Item(s)