Honokiol
(HB0328)- Data
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Data
Product overview
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NameHonokiol
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Short descriptionPhosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor
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Biological descriptionPhosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor. Inhibits NO, prostaglandin E2 and TNF-α production. Inhibits NFκB and scavenges superoxide and peroxyl radicals. Shows anti-inflammatory, antitumor and anti-angiogenic actions.
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Biological actionInhibitor
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Purity>98%
- Citations
Properties
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Chemical name3,5'-Diallyl-4,2'-dihydroxybiphenyl
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Molecular Weight266.33
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Chemical structure
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Molecular FormulaC18H18O2
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CAS Number35354-74-6
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PubChem identifier72303
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SMILESC=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
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InChiInChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
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InChiKeyFVYXIJYOAGAUQK-UHFFFAOYSA-N
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MDL numberMFCD00016674
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in DMSO (100 mM) and in ethanol (100 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Honokiol
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Kim BH et al (2008) Acta Pharmacol Sin 29(1) : 113-22.PubMedID: 18158873Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Dikalov S et al (2008) Biochem Pharmacol 76(5) : 589-96.PubMedID: 18640101Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.
Yang SE et al (2002) Biochem Pharmacol 63(9) : 1641-51.PubMedID: 12007567Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.
Son HJ et al (2000) Planta Med 66(5) : 469-71.PubMedID: 10909270
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