Honokiol

(HB0328)

Product overview

  • Name
    Honokiol
  • Short description
    Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor
  • Biological description
    Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor. Inhibits NO, prostaglandin E2 and TNF-α production. Inhibits NFκB and scavenges superoxide and peroxyl radicals. Shows anti-inflammatory, antitumor and anti-angiogenic actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3,5'-Diallyl-4,2'-dihydroxybiphenyl
  • Molecular Weight
    266.33
  • Chemical structure
    Honokiol  [35354-74-6]
  • Molecular Formula
    C18H18O2
  • CAS Number
    35354-74-6
  • PubChem identifier
    72303
  • SMILES
    C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
  • InChi
    InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
  • InChiKey
    FVYXIJYOAGAUQK-UHFFFAOYSA-N
  • MDL number
    MFCD00016674

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100 mM) and in ethanol (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Honokiol

  • Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.

    Kim BH et al (2008) Acta Pharmacol Sin 29(1) : 113-22.
    PubMedID: 18158873
  • Honokiol is a potent scavenger of superoxide and peroxyl radicals.

    Dikalov S et al (2008) Biochem Pharmacol 76(5) : 589-96.
    PubMedID: 18640101
  • Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.

    Yang SE et al (2002) Biochem Pharmacol 63(9) : 1641-51.
    PubMedID: 12007567
  • Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.

    Son HJ et al (2000) Planta Med 66(5) : 469-71.
    PubMedID: 10909270

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