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Honokiol

(HB0328)

Product overview

Name
Honokiol
Short description
Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor
Biological description
Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor. Inhibits NO, prostaglandin E2 and TNF-α production. Inhibits NFκB and scavenges superoxide and peroxyl radicals. Shows anti-inflammatory, antitumor and anti-angiogenic actions.
Biological action
Inhibitor
Purity
>98%
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Chemical name
3,5'-Diallyl-4,2'-dihydroxybiphenyl
Molecular Weight
266.33
Chemical structure
Molecular Formula
C₁₈H₁₈O₂
CAS Number
35354-74-6
PubChem identifier
72303
SMILES
C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
InChi
InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChiKey
FVYXIJYOAGAUQK-UHFFFAOYSA-N
MDL number
MFCD00016674

Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Kim BH et al (2008) Acta Pharmacol Sin 29(1) : 113-22.
PubMedID: 18158873
Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Dikalov S et al (2008) Biochem Pharmacol 76(5) : 589-96.
PubMedID: 18640101
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.
Yang SE et al (2002) Biochem Pharmacol 63(9) : 1641-51.
PubMedID: 12007567
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.
Son HJ et al (2000) Planta Med 66(5) : 469-71.
PubMedID: 10909270