Honokiol

(HB0328)

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(HB0328)

Data

Product overview

Name
Honokiol
Short description
Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor
Biological description
Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor. Inhibits NO, prostaglandin E2 and TNF-α production. Inhibits NFκB and scavenges superoxide and peroxyl radicals. Shows anti-inflammatory, antitumor and anti-angiogenic actions.
Biological action
Inhibitor
Purity
>98%
Citations
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Chemical name
3,5'-Diallyl-4,2'-dihydroxybiphenyl
Molecular Weight
266.33
Chemical structure
Molecular Formula
C₁₈H₁₈O₂
CAS Number
35354-74-6
PubChem identifier
72303
SMILES
C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
InChi
InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChiKey
FVYXIJYOAGAUQK-UHFFFAOYSA-N
MDL number
MFCD00016674

Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100 mM) and in ethanol (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.

Kim BH et al (2008) Acta Pharmacol Sin 29(1) : 113-22.
PubMedID: 18158873
Honokiol is a potent scavenger of superoxide and peroxyl radicals.

Dikalov S et al (2008) Biochem Pharmacol 76(5) : 589-96.
PubMedID: 18640101
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.

Yang SE et al (2002) Biochem Pharmacol 63(9) : 1641-51.
PubMedID: 12007567
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.

Son HJ et al (2000) Planta Med 66(5) : 469-71.
PubMedID: 10909270

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