In my cart

You have no items in your shopping cart.

(-)-Huperzine A


Product overview

  • Name
    (-)-Huperzine A
  • Short description
    AChE inhibitor / NMDA receptor antagonist
  • Biological description
    Acetylcholinesterase inhibitor (Ki = 6.2 nM). Also NMDA receptor antagonist (Ki = 6 μM at PCP site). Blood brain barrier permeable. Promotes hippocampal neurogenesis. Displays potent antinociceptive and anticonvulsant properties. Also shows positive effects on improving cognitive and behavioural functions.
  • Alternative names
    Hup A.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    Chemical Structure of (-)-Huperzine A  [102518-79-6]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in DMSO or Ethanol
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (-)-Huperzine A

  • Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.

    Ma T et al (2013) Brain Res 1506 : 35-43.
    PubMedID: 23454433
  • Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.

    Park P et al (2010) Neurosci Lett 470(1) : 6-9.
    PubMedID: 20026382
  • The NMDA receptor ion channel: a site for binding of Huperzine A.

    Gordon RK et al (2001) J Appl Toxicol 21 Suppl 1 : S47-51.
    PubMedID: 11920920
  • Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.

    Saxena A et al (1994) Protein Sci 3(10) : 1770-8.
    PubMedID: 7849595
Support & Resources

Reviews & Product Guides