(-)-Huperzine A

(HB0001)

Product overview

  • Name
    (-)-Huperzine A
  • Short description
    AChE inhibitor / NMDA receptor antagonist
  • Biological description
    Acetylcholinesterase inhibitor (Ki = 6.2 nM). Also NMDA receptor antagonist (Ki = 6 μM at PCP site). Blood brain barrier permeable. Promotes hippocampal neurogenesis. Displays potent antinociceptive and anticonvulsant properties. Also shows positive effects on improving cognitive and behavioural functions.
  • Alternative names
    Hup A
  • Biological action
    Inhibitor
  • Purity
    >97%
  • Our products in action

Properties

  • Chemical name
    (1R,9S,13E)-1-Amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
  • Molecular Weight
    242.32
  • Chemical structure
    (-)-Huperzine A  [102518-79-6]
  • Molecular Formula
    C15H18N2O
  • CAS Number
    102518-79-6
  • PubChem identifier
    907504
  • SMILES
    CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in DMSO or Ethanol
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (-)-Huperzine A

  • Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.

    Ma T et al (2013) Brain Res 1506 : 35-43.
    PubMedID: 23454433
  • Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.

    Park P et al (2010) Neurosci Lett 470(1) : 6-9.
    PubMedID: 20026382
  • The NMDA receptor ion channel: a site for binding of Huperzine A.

    Gordon RK et al (2001) J Appl Toxicol 21 Suppl 1 : S47-51.
    PubMedID: 11920920
  • Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.

    Saxena A et al (1994) Protein Sci 3(10) : 1770-8.
    PubMedID: 7849595

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