I-BET 151 hydrochloride

(HB1446)

Product overview

  • Name
    I-BET 151 hydrochloride
  • Short description
    BET bromodomain inhibitor
  • Biological description
    BET bromodomain inhibitor. Inhibits cytokine-induced transcription of STAT targets and downregulates cytokine production. Shows anti-inflammatory and anti-cancer actions.
  • Alternative names
    I-BET151
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one hydrochloride
  • Molecular Weight
    451.9
  • Chemical structure
    I-BET 151 hydrochloride
  • Molecular Formula
    C23H21N5O3.HCl

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for I-BET 151 hydrochloride

  • The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers.

    Long J et al (2014) J Biol Chem 289(51) : 35494-502.
    PubMedID: 25355313
  • BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes.

    Chan CH et al (2015) Eur J Immunol 45(1) : 287-97.
    PubMedID: 25345375
  • Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151.

    Gallagher SJ et al (2014) Pigment Cell Melanoma Res 27(6) : 1126-37.
    PubMedID: 24924589

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