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Biological Data
| Biological description | Non-selective, competitive, cell permeable cAMP and cGMP PDE inhibitor, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor which increases cAMP levels. IBMX also enhances 3T3-L1 cell differentiation and promotes neural progenitor cell differentiation. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (75 mM), and in ethanol (50 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione |
| Chemical structure | ![IBMX [28822-58-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "IBMX [28822-58-4]") |
| Molecular Formula | C10H14N4O2 |
| SMILES | CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2 |
| InChi | InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) |
| InChiKey | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| Appearance | White to off-white solid |
References for IBMX
References are publications that support the biological activity of the product
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cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.
Lepski et al (2013) Front Cell Neurosci. 19 : 7:155 -
Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine affects rabbit ovaries and oviduct.
Sirotkin et al (2010) Eur J Pharmacol 643(1) : 145-51 -
Phosphodiesterase inhibitors suppress alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
Freitag et al (1998) Eur J Pharmacol 354(1) : 67-71
Publications
These publications cite the use of IBMX purchased from Hello Bio:
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Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning
Fieblinger T et al (2022) EMBO Rep 23(8) : e54361 -
PACmn for improved optogenetic control of intracellular cAMP
Yang S et al (2021) BMC Biol 19(1) : 227
Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.
![IBMX [28822-58-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3000_3.png "IBMX [28822-58-4]")
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