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Data

Product overview

  • Name
    IBMX
  • Short description
    Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.
  • Biological description
    Non-selective, competitive, cell permeable cAMP and cGMP PDE inhibitor, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor which increases cAMP levels. IBMX also enhances 3T3-L1 cell differentiation and promotes neural progenitor cell differentiation.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
  • Molecular Weight
    222.3
  • Chemical structure
    IBMX [28822-58-4]
  • Molecular Formula
    C10H14N4O2
  • CAS Number
    28822-58-4
  • PubChem identifier
    3758
  • SMILES
    CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
  • InChi
    InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
  • InChiKey
    APIXJSLKIYYUKG-UHFFFAOYSA-N
  • MDL number
    MFCD00005584
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (75 mM), and in ethanol (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for IBMX

  • cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.

    Lepski et al (2013) Front Cell Neurosci. 19 : 7:155
    PubMedID: 24065885
  • Phosphodiesterase inhibitors suppress alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.

    Freitag et al (1998) Eur J Pharmacol 354(1) : 67-71
    PubMedID: 9726632
  • Phosphodiesterase inhibitor 3-isobutyl-methyl-xanthine affects rabbit ovaries and oviduct.

    Sirotkin et al (2010) Eur J Pharmacol 643(1) : 145-51
    PubMedID: 20599929
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