Ibotenic acid

(HB0330)

Product overview

  • Name
    Ibotenic acid
  • Short description
    Non-selective NMDA / mGlu receptor agonist
  • Biological description
    Non-selective NMDA and mGlu receptor agonist (EC50 values are 17, 43, 110, >1000 and >1000 μM for mGlu5a, mGlu1a, mGlu2, mGlu4a and mGlu6 receptors respectively). Shows excitotoxic actions. Used for cognitive dysfunction models for neurodegenerative disease research.
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid
  • Molecular Weight
    158.11
  • Chemical structure
    Ibotenic acid  [2552-55-8]
  • Molecular Formula
    C5H6N2O4
  • CAS Number
    2552-55-8
  • PubChem identifier
    1233
  • SMILES
    C1=C(ONC1=O)C(C(=O)O)N
  • InChi
    InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
  • InChiKey
    IRJCBFDCFXCWGO-UHFFFAOYSA-N
  • MDL number
    MFCD00069294

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (10mM) and in 0.1M NaOH (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ibotenic acid

  • Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.

    Hermit MB et al (2004) Eur J Pharmacol 486(3) : 241-50.
    PubMedID: 14985045
  • Neurochemical and behavioral effects of the intrahippocampal co-injection of beta-amyloid protein1-40 and ibotenic acid in rats.

    Li Y et al (2005) Life Sci 76(11) : 1189-97.
    PubMedID: 15642590
  • Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.

    Bräuner-Osborne H et al (1998) Eur J Pharmacol 350(2-3) : 311-6.
    PubMedID: 9696422
  • Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.

    Perkins MN et al (1982) Neurosci Lett 32(1) : 65-8.
    PubMedID: 6755315