Ibrutinib

(HB4204)

Product overview

  • Name
    Ibrutinib
  • Short description
    Potent, selective Bruton's tyrosine kinase (BTK) inhibitor.
  • Biological description
    Potent and selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM).
  • Purity
    >98%
  • Our products in action

Properties

  • Molecular Weight
    440.5
  • Chemical structure
    Ibrutinib [936563-96-1]
  • CAS Number
    936563-96-1
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Reviews & Product Guides