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Product overview

  • Name
  • Short description
    Potent, selective Bruton's tyrosine kinase (BTK) inhibitor.
  • Biological description
    Potent and selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM).
  • Purity
  • Citations


  • Molecular Weight
  • Chemical structure
    Ibrutinib [936563-96-1]
  • CAS Number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
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