Product overview

  • Name
    ICA 069673
  • Short description
    Kv7.4 channel activator
  • Biological description
    Kv7.4 channel activator. Also Kv7.2/7.3 and Kv7.3/7.5 channel activator (EC50 values are 0.69 and 14.3 µM respectively). Displays no or little activity at Kv11.1, Nav1.5, Kv7.1 and GABAA channels.
  • Biological action
    Activator
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
  • Molecular Weight
    269.63
  • Chemical structure
    ICA 069673  [582323-16-8]
  • Molecular Formula
    C11H6ClF2N3O
  • CAS Number
    582323-16-8

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (25mM)

References for ICA 069673

  • Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.

    Brueggemann LI et al (2014) Mol Pharmacol 86(3) : 330-41.
    PubMedID: 24944189
  • N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.

    Amato G et al (2011) ACS Med Chem Lett 2(6) : 481-4.
    PubMedID: 24900334

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