Product overview

  • Name
    ICG 001
  • Short description
    Selective, competitive inhibitor of β-catenin/CBP interaction
  • Biological description
    Selective and competitive inhibitor of β-catenin/ CREB-binding protein (CBP) interaction (IC50 = 3.0 µM). Exhibits little activity on β-catenin/p300. Also inhibits TGF-β1 induced α-SMA induction. Displays cardioprotective and apoptosis inducing properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
  • Molecular Weight
    548.63
  • Chemical structure
    ICG 001  [847591-62-2]
  • Molecular Formula
    C33H32N4O4
  • CAS Number
    847591-62-2

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ICG 001

  • The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium.

    Sasaki T et al (2013) PLoS One 8(9) : e75010.
    PubMedID: 24069374
  • ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription.

    Eguchi M et al (2005) Med Chem 1(5) : 467-72.
    PubMedID: 16787331
  • A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].

    Emami KH et al (2004) Proc Natl Acad Sci U S A 101(34) : 12682-7.
    PubMedID: 15314234
  • Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)

    Zhou B et al (2012) J Biol Chem 287(10) : 7026-38.
    PubMedID: 22241478

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