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Product overview

  • Name
    ICG 001
  • Short description
    Selective, competitive inhibitor of β-catenin/CBP interaction
  • Biological description
    Selective and competitive inhibitor of β-catenin/ CREB-binding protein (CBP) interaction (IC50 = 3.0 µM). Exhibits little activity on β-catenin/p300. Also inhibits TGF-β1 induced α-SMA induction. Displays cardioprotective and apoptosis inducing properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    ICG 001  [847591-62-2]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ICG 001

  • The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium.

    Sasaki T et al (2013) PLoS One 8(9) : e75010.
    PubMedID: 24069374
  • ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription.

    Eguchi M et al (2005) Med Chem 1(5) : 467-72.
    PubMedID: 16787331
  • A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].

    Emami KH et al (2004) Proc Natl Acad Sci U S A 101(34) : 12682-7.
    PubMedID: 15314234
  • Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)

    Zhou B et al (2012) J Biol Chem 287(10) : 7026-38.
    PubMedID: 22241478
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