In my cart

You have no items in your shopping cart.

ICI 182,780 (Fulvestrant)

(HB2501)
Data

Product overview

  • Name
    ICI 182,780 (Fulvestrant)
  • Short description
    Estrogen receptor (ER) antagonist and high affinity GPER agonist
  • Biological description
    Estrogen receptor (ER) antagonist (Ki values are 1 and 3.6 nM at ERα and ERβ respectively). Shows no agonist activity and is devoid of estrogenic activity. Also a high affinity agonist at GPER (GPR30). Down-regulates the ER and impairs nuclear shuttling and dimerization of the receptor. Shows anticancer activity. Active in vivo.
  • Alternative names
    Fulvestrant
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
  • Molecular Weight
    606.77
  • Chemical structure
    ICI 182,780
  • Molecular Formula
    C32H47F5O3S
  • CAS Number
    129453-61-8

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ICI 182,780 (Fulvestrant)

  • Emerging data on the efficacy and safety of fulvestrant, a unique antiestrogen therapy for advanced breast cancer.

    Scott SM et al (2011) Expert Opin Drug Saf 10(5) : 819-26.
    PubMedID: 21699443
  • Antagonists selective for estrogen receptor alpha.

    Sun J et al (2002) Endocrinology 143(3) : 941-7.
    PubMedID: 11861516
  • Estrogen and its receptors in cancer.

    Chen GG et al (2008) Med Res Rev 28(6) : 954-74.
    PubMedID: 18642351
  • Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: implications for their mechanism of action.

    Dudley MW et al (2000) Proc Natl Acad Sci U S A 97(7) : 3696-701.
    PubMedID: 10725345
Support & Resources

Reviews & Product Guides