Icilin

(HB1153)

Product overview

  • Name
    Icilin
  • Short description
    Potent TRPM8 channel agonist
  • Biological description
    Potent TRPM8 channel agonist. Approx 200-fold more potent than methanol (EC50 values of 0.36 and 66.7 µM for icilin and methanol respectively). Cooling agent that also activates TRPA1 cold channel. Also TRPV3 channel inhibitor (IC50 = 0.5 µM).
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one
  • Molecular Weight
    311.3
  • Chemical structure
    Icilin  [36945-98-9]
  • Molecular Formula
    C16H13N3O4
  • CAS Number
    36945-98-9

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Icilin

  • Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.

    Behrendt HJ et al (2004) Br J Pharmacol 141(4) : 737-45.
    PubMedID: 14757700
  • ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

    Story GM et al (2003) Cell 112(6) : 819-29.
    PubMedID: 12654248
  • Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3.

    Sherkheli MA et al (2012) ScientificWorldJournal 2012 : 982725
    PubMedID: 22548000
  • Identification of a cold receptor reveals a general role for TRP channels in thermosensation.

    McKemy DD et al (2002) Nature 416(6876) : 52-8.
    PubMedID: 11882888

Reviews & Product Guides