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Product overview

  • Name
    iCRT 14
  • Short description
    Potent CRT inhibitor
  • Biological description
    Potent Catenin-responsive transcription (CRT) inhibitor (IC50 = 40.3 nM). Interferes with T cell factor (TCF) binding to DNA, also small molecule Wnt inhibitor. Exhibits little or no effect on β-catenin interaction with E-caderin or α-catenin. Inhibits proliferation and displays antitumor properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H -pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion
  • Molecular Weight
  • Chemical structure
    iCRT 14  [677331-12-3]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (75mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for iCRT 14

  • An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.

    Gonsalves FC et al (2011) Proc Natl Acad Sci U S A 108(15) : 5954-63.
    PubMedID: 21393571
  • Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis.

    Marlow H et al (2013) Dev Biol 380(2) : 324-34.
    PubMedID: 23722001
  • Winning WNT: race to Wnt signaling inhibitors.

    Watanabe K et al (2011) Proc Natl Acad Sci U S A 108(15) : 5929-30.
    PubMedID: 21451134
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