In my cart

You have no items in your shopping cart.


Product overview

  • Name
    IDRA 21
  • Short description
    AMPA receptor positive allosteric modulator
  • Biological description
    AMPA receptor positive allosteric modulator. Enhances long term potentiation and inhibits AMPA receptor desensitization. Increases excitatory synaptic strength. Displays positive effects on cognition in several animal models. Blood brain barrier permeable.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide
  • Molecular Weight
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for IDRA 21

  • The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.

    Malkova L et al (2011) Neuropharmacology 60(7-8) : 1262-8.
    PubMedID: 21185313
  • 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity.

    Impagnatiello F et al (1997) Proc Natl Acad Sci U S A 94(13) : 7053-8.
    PubMedID: 9192690
  • 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.

    Zivkovic I et al (1995) J Pharmacol Exp Ther 272(1) : 300-9.
    PubMedID: 7815345
Support & Resources