Product overview

  • Name
    Ifenprodil
  • Short description
    Non-competitive GluN2B subunit selective NMDA receptor antagonist
  • Biological description
    Non-competitive GluN2B subunit selective NMDA receptor antagonist (IC50 = 0.15 μM). Selective over GluN2A, GluN2C and GluN2D subunits (IC50 values are >30 μM). Shows age and activation-dependent anticonvulsant activity and neuroprotective effects.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemitartrate
  • Molecular Weight
    400.49
  • Chemical structure
    Ifenprodil  [23210-58-4]
  • Molecular Formula
    C21H27NO2.½C4H6O6
  • CAS Number
    23210-58-4
  • PubChem identifier
    656586
  • SMILES
    CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
  • InChi
    InChI=1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
  • InChiKey
    DMPRDSPPYMZQBT-CEAXSRTFSA-N
  • MDL number
    MFCD01529999

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (15mM, gentle warming)

References for Ifenprodil

  • Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action.

    Williams K (2001) Curr Drug Targets 2(3) : 285-98.
    PubMedID: 11554553
  • Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.

    Reynolds IJ et al (1989) Mol Pharmacol 36(5) : 758-65.
    PubMedID: 2555674
  • Age and activation determines the anticonvulsant effect of ifenprodil in rats.

    Mareš P (2014) Naunyn Schmiedebergs Arch Pharmacol 387(8) : 753-61.
    PubMedID: 24807824
  • Ifenprodil effects on GluN2B-containing glutamate receptors.

    Amico-Ruvio SA et al (2012) Mol Pharmacol 82(6) : 1074-81.
    PubMedID: 22936815