Indo-1 AM

(HB0790)

Product overview

  • Name
    Indo-1 AM
  • Short description
    Calcium sensitive fluorescent dye
  • Alternative names
    Indo-1/AM; Indo-1 acetoxymethylester
  • Biological description
    Cell permeable calcium sensitive flouresecent dye. Binds to Ca2+ (Kd = 0.25 µM). Ratiometric and excited by UV light. Hydrolysed into Indo-1 by cytoplasmic esterases. May be used for monitoring Ca<2+> levels. Inhibits renal proximal tubule cell volume regulation.
  • Biological action
    Dyes & stains
  • Purity
    >95%
  • Our products in action

Properties

  • Chemical name
    1-[2-Amino-5-(6-carboxyindol-2-yl)phenoxy]-2-(2\'-amino-5\'-methylphenoxy)ethane-N,N,N\',N\'-tetraacetic acid, pentaacetoxymethylester
  • Molecular Weight
    1009.9
  • Chemical structure
    Indo-1 AM  [112926-02-0]
  • Molecular Formula
    C47H51N3O22
  • CAS Number
    112926-02-0

Storing and Using Your Product

  • Storage instructions
    -20°C

References for Indo-1 AM

  • The fluorescent calcium indicator indo-1/AM inhibits renal proximal tubule cell volume regulation.

    Kanli H et al (1992) Ann Clin Lab Sci 22(4) : 236-44.
    PubMedID: 1503391
  • The source of epifluorescence in isolated perfused heart loaded with fura 2-AM or indo 1-AM.

    Shinozaki T et al (1993) Heart Vessels 8(2) : 79-84.
    PubMedID: 8314741
  • Calcium mobilization in human platelets using indo-1 and flow cytometry.

    Jennings LK et al (1989) Blood 74(8) : 2674-80.
    PubMedID: 2510834
  • A new generation of Ca2+ indicators with greatly improved fluorescence properties.

    Grynkiewicz G et al (1985) J Biol Chem 260(6) : 3440-50.
    PubMedID: 3838314

Reviews & Product Guides