(-)-Indolactam V

(HB0002)

Product overview

  • Name
    (-)-Indolactam V
  • Short description
    Synthetic PKC activator
  • Biological description
    Synthetic protein kinase C (PKC) inhibitor. Also induces embryonic stem cell differentiation. Displays tumor promoting properties with mitogenic and comitogenic activating effects.
  • Biological action
    Activator
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
  • Molecular Weight
    301.38
  • Chemical structure
    (-)-Indolactam V  [90365-57-4]
  • Molecular Formula
    C17H23N3O2
  • CAS Number
    90365-57-4

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO (10mM)

References for (-)-Indolactam V

  • Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.

    Nakagawa Y et al (1997) Biosci Biotechnol Biochem 61(8) : 1415-7.
    PubMedID: 9301127
  • (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.

    Heikkilä J et al (1989) Biochem Biophys Res Commun 162(3) : 1207-13.
    PubMedID: 2764930
  • (-)-Indolactam V-induced mitogenesis in human fetal/neonatal and adult T cells: lower response of neonatal cells and possible regulatory role of monocytes in protein kinase C-mediated pathways.

    Papadogiannakis N (1995) Cell Immunol 162(2) : 288-94.
    PubMedID: 7743557
  • A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

    Chen S et al (2009) Nat Chem Biol 5(4) : 258-65.
    PubMedID: 19287398

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