Ionomycin free acid

(HB1002)

Product overview

  • Name
    Ionomycin free acid
  • Short description
    Calcium ionophore. Stimulates cytokine production.
  • Biological description

    Potent calcium ionophore which shows selectivity for Ca2+ over Mg2+ and K+. Acts as a Ca2+ carrier. Ionomycin calcium salt also available..

    Directly stimulates store-regulated cation entry across biological membranes to enhance Ca2+ influx and increase intracellular Ca2+ concentration.

    Synergies with with phorbol myristate acetate (PMA) to enhance activation of PKC. Frequently used in combination with PMA to stimulate T-cell activation and intracellular production of cytokines.

    Also induces apoptosis.

    Calcium ionophore A23187 also available.

  • Biological action
    Antibiotic
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
  • Molecular Weight
    709.01
  • Molecular Formula
    C41H72O9
  • CAS Number
    56092-81-0
  • PubChem identifier
    6912226
  • SMILES
    C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\O
  • InChiKey
    PGHMRUGBZOYCAA-ADZNBVRBSA-N
  • MDL number
    MFCD06798385
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    -20 °C;
  • Solubility overview
    Soluble in ethanol (10 mM) and DMSO (10 mM)

References for Ionomycin free acid

  • Characterization of ionomycin as a calcium ionophore.

    Liu C et al (1978) J Biol Chem 253(17) : 5892-4.
    PubMedID: 28319
  • Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.

    Kauffman RF et al (1980) J Biol Chem 255(7) : 2735-9.
    PubMedID: 6766939
  • PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells.

    Han S et al (2013) PLoS One 8(10) : e76717.
    PubMedID: 24130787

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