Product overview

  • Name
    IOX 1
  • Short description
    JMJD histone demethylase inhibitor
  • Biological description
    JMJD histone demethylase inhibitor. Inhibits JMJD2A, JMJD2E, PHD2 and FIH (IC50 values are 1.7, 2.4, 14.3 and 20.5 µM respectively). Cell permeable.
  • Alternative names
    5-carboxy-8HQ; SID 85736331
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    8-Hydroxy-5-quinolinecarboxylic acid
  • Molecular Weight
    189.17
  • Chemical structure
    IOX 1  [5852-78-8]
  • Molecular Formula
    C10H7NO3
  • CAS Number
    5852-78-8

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in NaOH(aq) (100mM, 1eq. NaOH) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for IOX 1

  • Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

    King ON et al (2010) PLoS One 5(11) : e15535.
    PubMedID: 21124847
  • A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.

    Schiller R et al (2014) ChemMedChem 9(3) : 566-71.
    PubMedID: 24504543

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