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Isoguvacine hydrochloride

(HB0883)
Data

Product overview

  • Name
    Isoguvacine hydrochloride
  • Short description
    Selective GABAA receptor agonist
  • Biological description
    Selective GABAA receptor agonist (IC50 = 5.6 µM). Less potent than GABA. Shows anti-epileptic actions.
  • Biological action
    Agonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
  • Molecular Weight
    163.6
  • Chemical structure
    Isoguvacine hydrochloride  [68547-97-7]
  • Molecular Formula
    C6H9NO2.HCl
  • CAS Number
    68547-97-7
  • PubChem identifier
    155107
  • SMILES
    C1CNCC=C1C(=O)O.Cl
  • InChi
    InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
  • InChiKey
    SUWREQRNTXCCBL-UHFFFAOYSA-N
  • MDL number
    MFCD00055192

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Isoguvacine hydrochloride

  • Isoguvacine binding, uptake, and release: relation to the GABA system.

    White WF et al (1983) J Neurochem 40(6) : 1701-8.
    PubMedID: 6854327
  • Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.

    Wahab A et al (2009) Epilepsy Res 86(2-3) : 113-23.
    PubMedID: 19535226
  • Isoguvacine binding, uptake, and release: relation to the GABA system.

    White WF et al (1983) J Neurochem 40(6) : 1701-8.
    PubMedID: 6854327
  • Understanding your inhibitions: effects of GABA and GABAA receptor modulation on brain cortical metabolism.

    Nasrallah FA et al (2009) J Neurochem 108(1) : 57-71.
    PubMedID: 19014380
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