Isradipine

(HB1223)

Product overview

  • Name
    Isradipine
  • Short description
    L-type voltage gated calcium channel blocker
  • Biological description
    L-type voltage gated calcium channel blocker (EC50 = 1.4 nM). Highest affinity for Cav1.3 and Cav1.2 channels over Cav1.4. Displays neuroprotective properties. Blood brain barrier permeable.
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
  • Molecular Weight
    371.39
  • Chemical structure
    Isradipine  [75695-93-1]
  • Molecular Formula
    C19H21N3O5
  • CAS Number
    75695-93-1
  • PubChem identifier
    3784
  • SMILES
    CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
  • InChi
    InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
  • InChiKey
    HMJIYCCIJYRONP-UHFFFAOYSA-N
  • MDL number
    MFCD00153820
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (50mM) or ethanol (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Isradipine

  • The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.

    Ilijic E et al (2011) Neurobiol Dis 43(2) : 364-71.
    PubMedID: 21515375
  • Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.

    Sinnegger-Brauns MJ et al (2009) Mol Pharmacol 75(2) : 407-14.
    PubMedID: 19029287
  • L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease.

    Anekonda TS et al (2011) Neurobiol Dis 41(1) : 62-70.
    PubMedID: 20816785
  • PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta.

    Hof RP et al (1984) J Cardiovasc Pharmacol 6(3) : 399-406.
    PubMedID: 6202964

Reviews & Product Guides