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Ivermectin (IVM)


Product overview

  • Name
    Ivermectin (IVM)
  • Short description
    Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor
  • Biological description

    Ivermectin (IVM) is an anthelmintic and positive allosteric modulator of α7 nicotinic acetylcholine receptors. It also shows activity at purinergic P2X4 receptors.

    Ivermectin modulates glutamate- and GABA-activated chloride channels and potentiates glycine-gated currents at low concentrations (30 nM).

    Use in chemogenetics

    Ivermectin selectively activates the chemogenetic glutamate-gated chloride (GluCl) and glycine-gated chloride (GlyCl) channels which silence neuronal activity.

  • Alternative names
  • Purity
  • Citations


  • Chemical name
    22,23-Dihydroavermectin B1
  • Molecular Weight
  • Chemical structure
    Ivermectin (IVM) [70288-86-7]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in DMSO (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for Ivermectin (IVM)

  • Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

    Krause et al (1998) Mol Pharmacol 53(2) : 283-94
    PubMedID: 9463487
  • An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.

    Frazier et al (23720773) J Biol Chem 288(29) : 21029-42
  • Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

    Islam et al (2016) ACS Chem Neurosci 7(12) : 1647-1657
    PubMedID: 27611437
  • A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.

    Islam et al (2017) ACS Chem Neurosci 8(3) : 460-467
    PubMedID: 27958714
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