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Ivermectin (IVM)

(HB1958)
Data

Product overview

  • Name
    Ivermectin (IVM)
  • Short description
    Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor
  • Biological description

    Ivermectin (IVM) is an anthelmintic and positive allosteric modulator of α7 nicotinic acetylcholine receptors. It also shows activity at purinergic P2X4 receptors.


    Ivermectin modulates glutamate- and GABA-activated chloride channels and potentiates glycine-gated currents at low concentrations (30 nM).


    Use in chemogenetics

    Ivermectin selectively activates the chemogenetic glutamate-gated chloride (GluCl) and glycine-gated chloride (GlyCl) channels which silence neuronal activity.

  • Alternative names
    IVM
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    22,23-Dihydroavermectin B1
  • Molecular Weight
    875.1
  • Chemical structure
  • Molecular Formula
    C48H74O14
  • CAS Number
    70288-86-7
  • PubChem identifier
    6321424
  • SMILES
    CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
  • InChi
    InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,
  • InChiKey
    AZSNMRSAGSSBNP-XPNPUAGNSA-N
  • MDL number
    MFCD00869511
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for Ivermectin (IVM)

  • Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

    Krause et al (1998) Mol Pharmacol 53(2) : 283-94
    PubMedID: 9463487
  • An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.

    Frazier et al (23720773) J Biol Chem 288(29) : 21029-42
  • Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

    Islam et al (2016) ACS Chem Neurosci 7(12) : 1647-1657
    PubMedID: 27611437
  • A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.

    Islam et al (2017) ACS Chem Neurosci 8(3) : 460-467
    PubMedID: 27958714
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