IWP 2

(HB0344)

Product overview

  • Name
    IWP 2
  • Short description
    Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal.
  • Biological description
    Potent Wnt pathway inhibitor (IC50 = 27 nM) and PORCN inhibitor. Also inhibits Dishevelled-2 (Dvl2- a Wnt-Fz signalling component) and LRP5/6 phosphorylation without inducing axin stability. Also suppresses R1 ESC self-renewal. Blocks phagocytosis and secretion of pro-inflammatory cytokines.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    N-(6-Methyl-2-benzothiazolyl)-2-[(3 ,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
  • Molecular Weight
    466.6
  • Chemical structure
    IWP 2  [686770-61-6]
  • Molecular Formula
    C22H18N4O2S3
  • CAS Number
    686770-61-6
  • PubChem identifier
    2155128
  • SMILES
    CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (10mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for IWP 2

  • Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.

    Dawes LJ et al (2013) Invest Ophthalmol Vis Sci 54(3) : 1582-90.
    PubMedID: 23385791
  • Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells.

    Richards MH et al (2014) PLoS One 9(3) : e92159.
    PubMedID: 24647048
  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

    Chen B et al (2009) Nat Chem Biol 5(2) : 100-7.
    PubMedID: 19125156