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Product overview

  • Name
    IWP 2
  • Short description
    Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal.
  • Biological description
    Potent Wnt pathway inhibitor (IC50 = 27 nM) and PORCN inhibitor. Also inhibits Dishevelled-2 (Dvl2- a Wnt-Fz signalling component) and LRP5/6 phosphorylation without inducing axin stability. Also suppresses R1 ESC self-renewal. Blocks phagocytosis and secretion of pro-inflammatory cytokines.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    N-(6-Methyl-2-benzothiazolyl)-2-[(3 ,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
  • Molecular Weight
  • Chemical structure
    IWP 2  [686770-61-6]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (10mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for IWP 2

  • Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.

    Dawes LJ et al (2013) Invest Ophthalmol Vis Sci 54(3) : 1582-90.
    PubMedID: 23385791
  • Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells.

    Richards MH et al (2014) PLoS One 9(3) : e92159.
    PubMedID: 24647048
  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

    Chen B et al (2009) Nat Chem Biol 5(2) : 100-7.
    PubMedID: 19125156
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