Product overview

  • Name
    JIB 04
  • Short description
    Jumonji histone demethylase inhibitor
  • Biological description
    Jumonji histone demethylase inhibitor. Inhibits JARID1A, JMJD2E/2B/2A/D3/2C (IC50 values are 230, 340, 435, 445, 855 and 1100 nM respectively). Shows little activity at PHD2 (IC50 = > 6 µM) and TET1. Shows anti-cancer actions.
  • Alternative names
    JIB-04
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
  • Molecular Weight
    308.76
  • Chemical structure
    JIB 04  [199596-05-9]
  • Molecular Formula
    C17H13ClN4
  • CAS Number
    199596-05-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for JIB 04

  • A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.

    Wang L et al (2013) Nat Commun 4 : 2035
    PubMedID: 23792809

Reviews & Product Guides