JNJ 10191584 maleate

(HB1596)

Product overview

  • Name
    JNJ 10191584 maleate
  • Short description
    Potent, selective H4 receptor silent antagonist
  • Biological description
    Potent and selective H4 histamine receptor silent antagonist. Selective for human H4 over H3 by >540-fold (Ki values are 26 nM and 14.1 µM respectively). Inhibits chemotaxis of mast cells and eosinophils in vitro. Shows anti-inflammatory and antinociceptive actions.
  • Alternative names
    VUF 6002
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate
  • Molecular Weight
    394.81
  • Chemical structure
    JNJ 10191584 maleate  [869497-75-6]
  • Molecular Formula
    C13H15ClN4O.C4H4O4
  • CAS Number
    869497-75-6

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for JNJ 10191584 maleate

  • Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.

    Terzioglu N et al (2004) Bioorg Med Chem Lett 14(21) : 5251-6.
    PubMedID: 15454206
  • Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.

    Varga C et al (2005) Eur J Pharmacol 522(1-3) : 130-8.
    PubMedID: 16213481
  • Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.

    Venable JD et al (2005) J Med Chem 48(26) : 8289-98.
    PubMedID: 16366610
  • Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.

    Coruzzi G et al (2007) Eur J Pharmacol 563(1-3) : 240-4.
    PubMedID: 17382315

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