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JNJ 16259685


Product overview

  • Name
    JNJ 16259685
  • Short description
    Potent, selective, non-competitive mGlu1 antagonist
  • Biological description

    Potent, selective and non-competitive mGlu1 receptor antagonist (Ki = 0.34 nM at mGlu1a). 

    Displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, NMDA or AMPA receptors (IC50 = >10 μM). Blood-brain barrier permeable.

    Inhibits glutamate-induced Ca2+ mobilization (IC50 = 3.24 nM at recombinant rat mGlu1a receptor).

    Decreases drug and alcohol addiction behaviours in rodents. 

  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    JNJ 16259685  [409345-29-5]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in ethanol (100mM) and in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for JNJ 16259685

  • JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.

    Lavreysen H et al (2004) Neuropharmacology 47(7) : 961-72.
    PubMedID: 15555631
  • Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.

    Xie X et al (2010) Psychopharmacology (Berl) 208(1) : 1-11.
    PubMedID: 19847405
  • mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.

    Lum EN et al (2014) Neuropharmacology 79 : 679-87.
    PubMedID: 24467847
  • Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.

    Mabire D et al (2005) J Med Chem 48(6) : 2134-53.
    PubMedID: 15771457
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