(+)-JQ1

(HB1448)

Product overview

  • Name
    (+)-JQ1
  • Short description
    Potent, selective, competitive BET bromodomain inhibitor
  • Biological description
    Potent, selective and competitive BET bromodomain inhibitor (Kd values are 50 and 90 nM for binding to 1st and 2nd BRD4 bromodomains; IC50 values are 77 and 33 nM for 1st and 2nd BRD4 bromodomains). Displaces BRD4 fusion oncoprotein from chromatin in squamous carcinoma. Shows antiproliferative actions.
  • Alternative names
    (+)-SGCBD01
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]di azepine-6-acetic acid 1,1-dimethylethyl ester
  • Molecular Weight
    456.99
  • Chemical structure
    (+)-JQ1  [1268524-70-4]
  • Molecular Formula
    C23H25ClN4O2S
  • CAS Number
    1268524-70-4

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (+)-JQ1

  • Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.

    Asangani IA et al (2014) Nature 510(7504) : 278-82.
    PubMedID: 24759320
  • Selective inhibition of BET bromodomains.

    Filippakopoulos P et al (2010) Nature 468(7327) : 1067-73.
    PubMedID: 20871596
  • Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma.

    Trabucco SE et al (2015) Clin Cancer Res 21(1) : 113-22.
    PubMedID: 25009295

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