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Data

Product overview

  • Name
    JX 401
  • Short description
    Potent, reversible p38α MAPK inhibitor
  • Biological description
    Potent and reversible p38α MAPK inhibitor (IC50 = 32 nM) that isn't ATP-competitive. Membrane permeable. Exhibits little or no activity at p38γ. Inhibits Elk1 phosphorylation. Displays anti-inflmmatory properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
  • Molecular Weight
    355.49
  • Molecular Formula
    C21H25NO2S
  • CAS Number
    349087-34-9

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (75mM) or ethsnol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for JX 401

  • JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.

    Friedmann Y et al (2006) Mol Pharmacol 70(4) : 1395-405.
    PubMedID: 16847144
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