Product overview

  • Name
    K252c
  • Short description
    PKC inhibitor
  • Biological description
    Protein kinase C (PKC) inhibitor with selectivity over protein kinase A (IC50 value = 214 nM at PKC). Inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 µM respectively). Inhibits human cytomegalovirus and amyloid β fibrillization. Shows cytotoxic and anti-tumor actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
  • Molecular Weight
    311.34
  • Chemical structure
    K252c  [85753-43-1]
  • Molecular Formula
    C20H13N3O
  • CAS Number
    85753-43-1

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for K252c

  • Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds.

    Fabre S et al (1993) Bioorg Med Chem 1(3) : 196-6.
    PubMedID: 8081852
  • Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.

    Zimmermann A et al (2000) Antiviral Res 48(1) : 49-60.
    PubMedID: 11080540
  • Kinase inhibitors: not just for kinases anymore.

    McGovern SL et al (2003) J Med Chem 46(8) : 1478-83.
    PubMedID: 12672248
  • K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

    Nakanishi S et al (1986) J Antibiot (Tokyo) 39(8) : 1066-71.
    PubMedID: 3759658

Reviews & Product Guides