Prototypic, selective kainate receptor agonist. Potent excitant and neurotoxin.
Kainic acid is the prototypic, selective kainate receptor (KAR) agonist. Analog of L-Glutamate.
Kainic acid is a potent excitant and neurotoxin (shows ~30-fold more neurotoxic potency than L-Glutamate).
It induces various changes in vivo including recurrent seizures, behavioural changes, oxidative stress, glial activation and selective neuronal death.
Kainic acid exerts its neuroexcitatory action by binding to glutamate receptors to cause Ca2+ influx and triggering subsequent excitotoxic neuronal death pathway cascades.
It is widely used to model various neurodegenerative diseases and epilepsy.
We tested the Kainic acid and we are very happy with it. Hello Bio Kainic acid was used at 25 mg/kg i.p. and successfully induced status epilepticus. Verified customer, CNRS, France
Exactly as ordered - we ordered 50 mg kainic acid and it arrived swiftly. The batch display same EC50 and efficacy as all other batches, so we assume it is pure and an intact batch of the compound. Verified customer, University of Copenhagen
Very happy - service from Hello Bio is always friendly and quick. Kainic acid (KA) works as expected on AMPA receptors in HEK cells. Much cheaper than alternative suppliers. Verified customer, UCL
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Extracted from diginea simplex
The kainate receptor (KAR) agonist kainic acid induces neuronal oscillations in the gamma frequency band (35-100Hz). KAR activation leads to synchronous activity of excitatory and inhibitory network firing. Kainic acid is commonly used at concentrations of 400-600 nM to induce oscillations in acute brain slices. At a concentration of 550 nM, kainic acid from Hello Bio induces a strong gamma frequency neuronal oscillation (approx. 35Hz) within the CA3 region of the rat hippocampus (see Fig 1 above). Oscillations were abolished following kainic acid washout.
#Protocol 1: Oscillations assay
- Acute rat hippocampal slices were placed in an interface chamber and held at 30°C with a glass recording electrode placed in the CA3 region of the hippocampus.
- Control basal activity was recorded for 1 hr in the presence of aCSF before continuous perfusion of aCSF containing kainic acid at 550nM to induce oscillations.
- Oscillation activity was recorded once oscillations had stabilised (~2-3 hours).
- Kainic acid was then washed out and replaced with control aCSF.
- Data were analysed to create a power spectrum of the oscillation.
Storing and Using Your Product
Soluble in water (25mM, gentle warming)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Kainic acid
Kainic acid-mediated excitotoxicity as a model for neurodegeneration.Wang Q et al (2005) Mol Neurobiol 31(1-3) : 3-16.PubMedID: 15953808
Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.Fezza F et al (2014) Mol Cell Neurosci 62 : 1-9.PubMedID: 25064144
Identification and characterization of the ligand binding subunit of a kainic acid receptor using monoclonal antibodies and peptide mapping.Hampson DR et al (1989) J Biol Chem 264(22) : 13329-35.PubMedID: 2546953
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.Alt et al (2004) Neuropharmacology 46(6) : 793-806PubMedID: 15033339
AMPA Receptor Inhibition by Medium-Chain Fatty Acids as a Mechanism for Seizure Control in the MCT Ketogenic DietAugustin K(2017) Dissertation : 1:219
Regulation of AMPA receptors by type II-TARPsLemos S(2017) Dissertation : 1:349
Auxiliary subunits keep AMPA receptors compact during activation and desensitizationBaranovic and Plested (2018) bioRxiv https://doi.org : /10.1101/295105
Reviews & Product Guides
Works great. Compared KA from Hello Bio with another company's. Works just great but at an affordable price. Both seizures and neurotoxic cell death in hippocampus was as expected.
Very happy - service from Hello Bio is always friendly and quick. Kainic acid (KA) works as expected on AMPA receptors in HEK cells. Much cheaper than alternative suppliers.
Exactly as ordered - we ordered 50 mg kainic acid and it arrived swiftly. The batch display same EC50 and efficacy as all other batches, so we assume it is pure and an intact batch of the compound.