In my cart

You have no items in your shopping cart.

Kainic acid


Product overview

  • Name
    Kainic acid
  • Short description
    Prototypic, selective kainate receptor agonist. Potent excitant and neurotoxin.
  • Biological description

    Kainic acid is the prototypic, selective kainate receptor (KAR) agonist. Analog of L-Glutamate.

    Kainic acid is a potent excitant and neurotoxin (shows ~30-fold more neurotoxic potency than L-Glutamate).

    It induces various changes in vivo including recurrent seizures, behavioural changes, oxidative stress, glial activation and selective neuronal death.

    Kainic acid exerts its neuroexcitatory action by binding to glutamate receptors to cause Ca2+ influx and triggering subsequent excitotoxic neuronal death pathway cascades.

    It is widely used to model various neurodegenerative diseases and epilepsy.

  • Biological action
  • Purity
  • Customer comments

    We tested the Kainic acid and we are very happy with it. Hello Bio Kainic acid was used at 25 mg/kg i.p. and successfully induced status epilepticus. Verified customer, CNRS, France

  • Citations



  • Chemical name
    (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
  • Molecular Weight
  • Chemical structure
    Kainic acid  [487-79-6]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
    Extracted from diginea simplex
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid


  • Application notes

    The kainate receptor (KAR) agonist kainic acid induces neuronal oscillations in the gamma frequency band (35-100Hz). KAR activation leads to synchronous activity of excitatory and inhibitory network firing. Kainic acid is commonly used at concentrations of 400-600 nM to induce oscillations in acute brain slices. At a concentration of 550 nM, kainic acid from Hello Bio induces a strong gamma frequency neuronal oscillation (approx. 35Hz) within the CA3 region of the rat hippocampus (see Fig 1 above). Oscillations were abolished following kainic acid washout.


    #Protocol 1: Oscillations assay

    • Acute rat hippocampal slices were placed in an interface chamber and held at 30°C with a glass recording electrode placed in the CA3 region of the hippocampus.
    • Control basal activity was recorded for 1 hr in the presence of aCSF before continuous perfusion of aCSF containing kainic acid at 550nM to induce oscillations.
    • Oscillation activity was recorded once oscillations had stabilised (~2-3 hours). 
    • Kainic acid was then washed out and replaced with control aCSF. 
    • Data were analysed to create a power spectrum of the oscillation.


Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (25mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Kainic acid

  • Kainic acid-mediated excitotoxicity as a model for neurodegeneration.

    Wang Q et al (2005) Mol Neurobiol 31(1-3) : 3-16.
    PubMedID: 15953808
  • Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.

    Fezza F et al (2014) Mol Cell Neurosci 62 : 1-9.
    PubMedID: 25064144
  • Identification and characterization of the ligand binding subunit of a kainic acid receptor using monoclonal antibodies and peptide mapping.

    Hampson DR et al (1989) J Biol Chem 264(22) : 13329-35.
    PubMedID: 2546953
  • Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

    Alt et al (2004) Neuropharmacology 46(6) : 793-806
    PubMedID: 15033339
Our products in action
The following papers have cited the use of Kainic acid (HB0355) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • AMPA Receptor Inhibition by Medium-Chain Fatty Acids as a Mechanism for Seizure Control in the MCT Ketogenic Diet

    Augustin K(2017) Dissertation : 1:219
  • Regulation of AMPA receptors by type II-TARPs

    Lemos S(2017) Dissertation : 1:349
Support & Resources


  • Verified customer, CNRS, France

    We tested the Kainic acid and we are very happy with it. Hello Bio Kainic acid was used at 25 mg/kg i.p. and successfully induced status epilepticus.