KB-R7943 mesylate

(HB1133)

Product overview

  • Name
    KB-R7943 mesylate
  • Short description
    Selective, reverse mode Na+ / Ca2+ exchange inhibitor
  • Biological description
    Selective, reverse mode Na+/Ca2+ exchange inhibitor (IC50 = 0.7 µM). Also potent mitochondrial Ca2+ uniporter inhibitor (Ki = 5.5 µM). Does not affect Na+-dependent transport systems or ionotropic glutamate receptors. Decreases nitric oxide and hydoxyradical formation. Displays cardioprotective properties.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate
  • Molecular Weight
    427.49
  • Chemical structure
    KB-R7943 mesylate  [182004-65-5]
  • Molecular Formula
    C16H17N3O3S.CH3SO3H
  • CAS Number
    182004-65-5

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)

References for KB-R7943 mesylate

  • The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.

    Santo-Domingo J et al (2007) Br J Pharmacol 151(5) : 647-54.
    PubMedID: 17471180
  • Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.

    Hoyt KR et al (1998) Mol Pharmacol 53(4) : 742-9.
    PubMedID: 9547366
  • Role of nitric oxide and free radicals in cardioprotection by blocking Na+/H+ and Na+/Ca2+ exchange in rat heart.

    Maczewski M et al (2003) Eur J Pharmacol 461(2-3) : 139-47.
    PubMedID: 12586209

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