KC 12291 hydrochloride

(HB1019)

Product overview

  • Name
    KC 12291 hydrochloride
  • Short description
    Atypical voltage-gated sodium channel blocker
  • Biological description
    Atypical voltage-gated sodium channel blocker. Reduces sustained Na+ channel current and inhibits peak current. Inhibits veratridine- and LPC-induced sustained sodium current contractures (IC50 values are 0.55 and 0.79 µM respectively). Shows cardioprotective, antiischemic and bradycardic actions.
  • Biological action
    Blocker
  • Purity
    >97%
  • Our products in action

Properties

  • Chemical name
    3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
  • Molecular Weight
    449.99
  • Chemical structure
    KC 12291 hydrochloride  [181936-98-1]
  • Molecular Formula
    C22H27N3O3S.HCl
  • CAS Number
    181936-98-1

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in water (25mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for KC 12291 hydrochloride

  • KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.

    John GW et al (2004) Cardiovasc Drug Rev 22(1) : 17-26.
    PubMedID: 14978516
  • Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.

    Létienne R et al (2006) Eur J Pharmacol 530(3) : 243-9.
    PubMedID: 16368090
  • Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.

    Tamareille S et al (2002) J Cardiovasc Pharmacol 40(3) : 346-55.
    PubMedID: 12198320

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