Kenpaullone

(HB1266)

Product overview

  • Name
    Kenpaullone
  • Short description
    Potent CDK inhibitor. Also GSK-3 inhibitor. Generates iPSCs.
  • Biological description
    Potent, ATP-competitive CDK inhibitor (IC50 values are 0.4, 0.68, 7.5, 0.85 µM for CDK1/cyclinB, CDK2/cyclinA, CDK2/cyclinE and CDK5/p25 respectively). Also inhibits GSK-3β and LCK (IC50 values are 0.23 and 0.47 µM respectively) Displays reduced activity for other kinases (IC50 values are 15, 20, 20, 9 µM for c-src, casein kinase 2, ERK1 and ERK2 respectively). Also Generates iPSCs. Displays antiproliferative properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
  • Molecular Weight
    327.18
  • Chemical structure
    Kenpaullone  [142273-20-9]
  • Molecular Formula
    C16H11BrN2O
  • CAS Number
    142273-20-9

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM, gentle warming) or ethanol (5mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Kenpaullone

  • Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

    Zaharevitz DW et al (1999) Cancer Res 59(11) : 2566-9.
    PubMedID: 10363974
  • The specificities of protein kinase inhibitors: an update.

    Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
    PubMedID: 12534346
  • New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells.

    Brault L et al (2005) Eur J Med Chem 40(8) : 757-63.
    PubMedID: 16122578