Ketanserin tartrate

(HB1641)

Product overview

  • Name
    Ketanserin tartrate
  • Short description
    Selective 5-HT2 receptor antagonist
  • Biological description
    Selective 5-HT2 serotonin receptor antagonist. Shows dose-dependent α-1 adrenoceptor inhibition. Used to differentiate between 5-HT1D subtypes by showing selectivity for 5-HT1Dα. Shows antihypertensive, antidepressant and anti-leishmaniasis actions.
  • Alternative names
    R 41 468
  • Biological action
    Antagonist
  • Purity
    >97%
  • Our products in action

Properties

  • Chemical name
    3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate
  • Molecular Weight
    545.52
  • Chemical structure
    Ketanserin tartrate  [83846-83-7]
  • Molecular Formula
    C22H22FN3O3.C4H6O6
  • CAS Number
    83846-83-7

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ketanserin tartrate

  • Antihypertensive properties of ketanserin (R 41 468).

    Vanhoutte PM et al (1983) Fed Proc 42(2) : 182-5.
    PubMedID: 6295821
  • Differences in the effects of ketanserin and GR127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein.

    Razzaque Z et al (1995) Eur J Pharmacol 283(1-3) : 199-206.
    PubMedID: 7498311
  • Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani.

    Singh S et al (2014) Parasitol Res 113(6) : 2161-8.
    PubMedID: 24728519

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