KT 5720

(HB0361)

Product overview

  • Name
    KT 5720
  • Short description
    Potent, selective PKA inhibitor
  • Biological description
    Potent and selective protein kinase A inhibitor (Ki = 60 nM). Arrests skin fibroblasts in the G1 stage. Reverses multi-drug resistance in leukaemia and attenuates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the dorsal root ganglion (DRG). Cell-permeable.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Images

Properties

  • Chemical name
    (9R,10S,12S)-2,3,9,10,11,12-Hexahyd ro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
  • Molecular Weight
    537.61
  • Chemical structure
    KT 5720  [108068-98-0]
  • Molecular Formula
    C32H31N3O5
  • CAS Number
    108068-98-0
  • PubChem identifier
    3844
  • SMILES
    CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
  • InChi
    InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)
  • InChiKey
    ZHEHVZXPFVXKEY-UHFFFAOYSA-N
  • MDL number
    MFCD00132118

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for KT 5720

  • K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases.

    Kase H et al (1987) Biochem Biophys Res Commun 142(2) : 436-40.
    PubMedID: 3028414
  • In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: implications on hematological malignancies.

    Galski H et al (2006) Leuk Res 30(9) : 1151-8.
    PubMedID: 16542724
  • Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

    Gadbois DM et al (1992) Proc Natl Acad Sci U S A 89(18) : 8626-30.
    PubMedID: 1528872
  • Novel role of KT5720 on regulating hyperpolarization-activated cyclic nucleotide-gated channel activity and dorsal root ganglion neuron excitability.

    Cheng Q et al (2013) DNA Cell Biol 32(6) : 320-8.
    PubMedID: 23713946
The following papers have cited the use of KT 5720 (HB0361) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.

    Park et al(2016) J Neurosci 36(2) : 622-31
    PubMedID: 26758849

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