KT 5823

(HB1316)

Product overview

  • Name
    KT 5823
  • Short description
    Potent, selective PKG inhibitor
  • Biological description
    Potent and selective protein kinase G (PKG) inhibitor (Ki = 0.234 µM). Exhibits selectivity for PKG over PKA and PKC (Ki values are >10.0 and 4.0 µM for PKA and PKC respectively). Arrests cell cycle at GO/G1 boundary and also modulates Na+/I- symporter (NIS). Displays pro-apoptotic properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (9S,10R,12R)-2,3,9,10,11,12-Hexahyd ro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-dii ndolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodi azocine-10-carboxylic acid, methyl ester
  • Molecular Weight
    495.53
  • Molecular Formula
    C29H25N3O5
  • CAS Number
    126643-37-6

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for KT 5823

  • Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

    Gadbois DM et al (1992) Proc Natl Acad Sci U S A 89(18) : 8626-30.
    PubMedID: 1528872
  • KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells.

    Beyer S et al (2011) Endocrinology 152(3) : 782-92.
    PubMedID: 21209020
  • Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.

    Chan SL et al (2003) Mol Hum Reprod 9(12) : 775-83.
    PubMedID: 14614039

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