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Biological Data

Biological description Potent and selective protein kinase G (PKG) inhibitor (Ki = 0.234 µM). Exhibits selectivity for PKG over PKA and PKC (Ki values are >10.0 and 4.0 µM for PKA and PKC respectively). Arrests cell cycle at GO/G1 boundary and also modulates Na+/I- symporter (NIS). Displays pro-apoptotic properties.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (9S,10R,12R)-2,3,9,10,11,12-Hexahyd ro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-dii ndolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodi azocine-10-carboxylic acid, methyl ester
Molecular Weight 495.53
Molecular Formula C29H25N3O5
CAS Number 126643-37-6
PubChem identifier 108152
SMILES [H][C@]18O[C@](N6C4=C3N1C2=CC=CC=C2C3=C7C(CN(C7=O)C)=C4C5=CC=CC=C56)([C@]([C@@](OC)=O)(OC)C8)C
InChiKey QTYMDECKVKSGSM-YMUMJAELSA-N

References for KT 5823

References are publications that support the biological activity of the product
  • KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells.

    Beyer S et al (2011) Endocrinology 152(3) : 782-92.
  • Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.

    Chan SL et al (2003) Mol Hum Reprod 9(12) : 775-83.
  • Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

    Gadbois DM et al (1992) Proc Natl Acad Sci U S A 89(18) : 8626-30.

3 Item(s)