Kynurenic acid

(HB0362)

Product overview

  • Name
    Kynurenic acid
  • Short description
    Endogenous ionotropic glutamate / nicotinic antagonist.
  • Biological description
    Endogenous, non-selective ionotropic glutamate receptor antagonist which acts as a non-competitive glycine site NMDAR antagonist. Also an α7 nicotinic receptor antagonist and GPR35 ligand. Blocks kainic acid neurotoxicity and displays neuroprotective, antiproliferative and antimigrative properties.
  • Alternative names
    Kynurenate; KYNA
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Images

Properties

  • Chemical name
    4-Hydroxyquinoline-2-carboxylic acid
  • Molecular Weight
    189.17
  • Chemical structure
    Kynurenic acid  [492-27-3]
  • Molecular Formula
    C10H7NO3
  • CAS Number
    492-27-3
  • PubChem identifier
    3845
  • SMILES
    C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O
  • InChi
    InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
  • InChiKey
    HCZHHEIFKROPDY-UHFFFAOYSA-N
  • MDL number
    MFCD00006753
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (75mM) and in 0.1M NaOH (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Kynurenic acid

  • 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones.

    Weber M et al (2001) J Neurochem 77(4) : 1108-15.
    PubMedID: 11359876
  • Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells.

    Walczak K et al (2014) Pharmacol Rep 66(1) : 130-6.
    PubMedID: 24905318
  • Kynurenate is neuroprotective following experimental brain injury in the rat.

    Hicks RR et al (1994) Brain Res 655(1-2) : 91-6.
    PubMedID: 7812795
  • Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

    Alt et al (2004) Neuropharmacology 46(6) : 793-806
    PubMedID: 15033339